282 Mep is no longer being manufactured for sale in Canada and is no longer available under any brand names. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
HEALTH CANADA ADVISORY
July 28, 2016
Health Canada has issued new information concerning the use of ASA - caffeine - meprobamate - codeine. To read the full report, visit Health Canada's website at www.hc-sc.gc.ca.
Previous advisories on 282 Mep were issued on August 29, 2013 and June 6, 2013.
Constipation: This medication can cause constipation or make existing constipation worse. If you have chronic constipation, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Dependence and withdrawal: Physical dependence, psychological dependence, and abuse have occurred with the use of this medication. When excessive dosage has continued for weeks or months, your doctor will likely advise you to reduce the dose gradually over a period of 1 to 2 weeks rather than stopping it suddenly.
Drowsiness/reduced alertness: This medication may reduce the mental or physical abilities required to carry out potentially dangerous tasks such as driving or operating machinery.
Head injury: People with head injuries should be monitored by their doctor while taking this medication, as it may worsen their condition or affect their breathing.
Gout: ASA may cause or worsen attacks of gout.
Kidneys: Excessive and prolonged therapy with this medication may promote kidney disease.
Other medical conditions: If you have any of the following conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed:
- asthma and other allergic conditions
- bleeding tendencies
- certain blood disorders
- reduced kidney or liver function
Surgery: Do not take this medication for 5 to 7 days before any surgery, including dental surgery, unless otherwise directed by your doctor or dentist.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. As well, one ingredient of this medication, codeine, is converted to morphine (a more powerful painkiller) in the body. Some people convert codeine into morphine much faster and more completely than others, resulting in higher levels of morphine in the body and the risk of a morphine overdose for the breast-feeding baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of meprobamate have not been established for use by children under the age of 6 years.
The use of ASA may be associated with the development of Reye's syndrome in children and teenagers who have illnesses accompanied by fever, especially influenza and chickenpox. ASA should not be given to, or used by, children or teenagers who have chickenpox or flu symptoms, unless a doctor is consulted.
ASA is one of the most frequent causes of accidental poisoning in toddlers and infants. Medications that contain ASA should be kept out of the reach of all children.
Seniors: Seniors are more likely to become drowsy as a result of the side effects of this medication.