Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Diabetes: Both elevation and lowering of blood sugar levels have been reported with desipramine use. People with diabetes or hypoglycemia (low blood sugar) should monitor their blood glucose levels closely while taking this medication.
Drowsiness/reduced alertness: Desipramine may reduce the mental or physical abilities required for the performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Use appropriate caution until you determine how this medication affects you.
Heart rhythm: Desipramine can cause abnormal heart rhythms, particularly when taken in high doses. Therefore, seniors and those with a history of heart disease should take desipramine with caution.
Medical conditions: If you have thyroid disease, a history of seizures, mania (desipramine may induce mania in people with a history of mania or bipolar disorder), urinary retention, narrow-angle glaucoma, or increased eye pressure, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Suicidal thoughts: Desipramine may increase the risk of suicidal thoughts, especially when starting therapy or adjusting the dosage. Seek medical attention if there are any signs of worsening condition.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Desipramine passes into breast milk. If you are a breast-feeding mother and are taking desipramine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Seniors: Seniors should use this medication with caution, and should not exceed the recommended dose.