Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Antidepressant medication: Severe reactions are possible when selegiline is combined with tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. The combination of selegiline and antidepressants from these groups must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. Coma and death are also possible.
If you take any of these medications or have taken antidepressants recently, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Headache: If you experiencing a severe headache or other unusual symptoms while taking selegiline, report them to a doctor immediately.
Levodopa: Some people who take selegiline may experience a worsening of levodopa-associated side effects, such as unusual movements of the body. Report these effects to your doctor as soon as possible. Your doctor may help with these effects by reducing the dose of levodopa.
Maximum dose: Do not exceed the recommended daily dose of 10 mg of selegiline.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if selegiline passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.