Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergy: Before starting treatment with cefixime, make sure you tell your doctor about any adverse reactions you have had to medications, especially cefixime, cephalosporins, and penicillins. Some people allergic to penicillin may also be allergic to cephalosporins such as cefixime. If you have an allergic reaction, contact your doctor.
Antibiotic-associated colitis: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated colitis (or pseudomembranous colitis). Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking cefixime and contact your doctor as soon as possible.
Hemolytic anemia: Rarely, cefixime causes a condition where red blood cells are destroyed before the end of the cells' normal lifespan. This condition is called hemolytic anemia, which can cause severe health complications. People who notice symptoms of hemolytic anemia (unusual fatigue, yellowing of the eyes or skin, dark urine, or pale skin) should contact their doctor immediately.
Kidney function: People with reduced kidney function or kidney disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Overgrowth of organisms: Prolonged or repeated use of cefixime may result in an overgrowth of bacteria or fungi and organisms that are not killed by the medication. This can cause other infections, such as yeast infections, to develop.
Pregnancy: It is not known if cefixime is safe for use during pregnancy. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if cefixime passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children under 6 months old.