Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Fluid retention and heart failure: Rosiglitazone can cause fluid buildup in the body, which may lead to heart failure. Your doctor will monitor you for these problems. If you develop fluid buildup or swelling, shortness of breath, fatigue, or excessive weight gain while taking this medication, contact your doctor immediately. People with a history of heart failure should not take rosiglitazone.
Since the risk of heart failure and fluid buildup increases when rosiglitazone is used with other antidiabetes medications, rosiglitazone should only be used alone or in combination with a sulfonylurea (such as glyburide or gliclazide) OR metformin, but not with other diabetes medications (such as insulin), and not with both a sulfonylurea AND metformin together.
Fractures: Women taking rosiglitazone may be at an increased risk of bone fractures, especially of the upper arm, hand, and foot. Discuss the risk and benefits of using this medication with your doctor.
Heart attack and chest pain: Rosiglitazone can increase the risk of chest pain (angina) and heart attacks. If you have underlying heart disease, or are at a high risk of heart attack, discuss the risks and benefits of using this medication with your doctor. This medication is not recommended for people who take nitrates (e.g., nitroglycerin, isosorbide mononitrate, isosorbide dinitrate), which are used to relieve chest pain.
Liver: Rosiglitazone may cause liver damage. Your doctor will monitor your liver function while you are taking this medication. Report any signs of liver problems to your doctor at once. These signs include:
- abdominal or stomach pain
- dark urine
- loss of appetite
- nausea or vomiting
- unusual tiredness or weakness
- yellow eyes or skin
Loss of blood glucose control: Loss of blood glucose control can occur during times of acute stress such as fever, trauma, infection, or surgery. During these times, your doctor may temporarily stop this medication and use insulin until you have recovered.
Ovulation: Some women using rosiglitazone may start having menstrual periods, even after not having a period due to a medical condition (e.g., polycystic ovary syndrome). As a result, you could get pregnant while taking rosiglitazone. Talk to your doctor about the need for birth control.
Vision: Rosiglitazone may cause swelling of the retina in the eye. If you experience any vision changes while taking rosiglitazone, contact your doctor immediately.
Pregnancy: This medication should not be used during pregnancy. Usually insulin is used to control high blood sugars during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if rosiglitazone passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. Children:
The safety and effectiveness of this medication have not been established for children less than 18 years of age.