Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Diarrhea: Although less common with antibiotics applied to the skin, people using this medication may develop diarrhea caused by an infection with the bacteria C. difficile. If you have loose, watery, and bloody bowel movements, with or without fever, or stomach cramps after using clindamycin topical solution, get medical attention as soon as possible. Diarrhea caused by C. difficile infection can lead to serious health problems if it is not properly treated.
Ointment caution: Polyethylene glycol (PEG) can be absorbed from open wounds and damaged skin. It is removed from the body by the kidneys. As with other PEG-based ointments, mupirocin ointment should not be used in conditions where absorption of large quantities of PEG is possible, especially in people with known kidney problems.
Overgrowth of organisms: Use of mupirocin occasionally allows the overgrowth of organisms not killed by the medication. If your condition worsens or does not improve in the expected time, call your doctor.
Pregnancy: The safety of this medication for the treatment of infections during pregnancy is unknown. If you are or may be pregnant, talk to your doctor about the benefits and risks of using mupirocin.
Breast-feeding: If you are breast-feeding, talk to your doctor about the benefits and risks of using this medication.
If you are using this medication to treat a cracked nipple, your doctor may advise you to use a breast pump to pump the milk from the affected breast while you are using this medication. The milk from the affected breast should be discarded.