Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Application: Avoid contact with the eyes, eyelids, corners of the nose, mouth, easily irritated areas, or other areas where treatment is not intended. If contact does occur, wash with plenty of lukewarm water. Do not apply clindamycin - tretinoin to severely inflamed skin or to open lesions. Do not use more of this medication than recommended by your doctor. Doing so will not speed up treatment and will irritate your skin.
Colitis: When applied to the skin, clindamycin is absorbed into the bloodstream and can cause colitis (inflammation of the colon). Contact your doctor immediately if you experience abdominal pain, cramps or bloating, severe watery diarrhea that may be bloody, or nausea and vomiting.
Other acne medications: Other acne medications and skin preparations should not be used at the same time as clindamycin - tretinoin, as it may cause increased skin irritation. If severe irritation occurs, stop using this medication and contact your doctor.
Overgrowth of organisms (super-infection): Prolonged or repeated use of this medication may allow certain types of bacteria, that are not killed by the antibiotic, to overgrow, causing unwanted infections. Bacteria that used to be susceptible to clindamycin may also overgrow, causing acne to return and not respond to this medication. Contact your doctor if you notice your acne worsening or you develop red or irritated patches after you have been using this medication for a while.
Skin irritation: Some people may experience temporary skin irritation, especially in early weeks of treatment. If excessive reactions occur and the skin becomes extremely red, swollen, and crusted, the medication should be stopped and you should contact your doctor.
Sunlight exposure: Exposure to sunlight, including ultraviolet sunlamps, may cause more irritation. Avoid or minimize this type of exposure while using tretinoin. If you cannot avoid exposure to sunlight, use sunscreen products (minimum SPF 15) and wear protective clothing over treated areas. If you get a sunburn, stop using this medication until skin redness and peeling resolves.
Pregnancy: This medication is not recommended for use during pregnancy. Women who may become pregnant should use an effective method of birth control while they are using this medication. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if clindamycin - tretinoin passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children less than 12 years of age.