Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Blood vessel conditions: The risk and benefits of using this medication for people with a history of thrombophlebitis or other blood clotting problems should be reviewed with a doctor. If you have vascular problems in the brain (e.g. stroke) or coronary artery disease, discuss the risks and benefits of using this medication with your doctor.
Calcium: Since this medication can influence the balance of calcium and phosphorous in the body, people with certain bone diseases, kidney impairment, prostate cancer, or cancer that has spread to the bone, should have their calcium levels monitored closely.
Contraception: Men receiving estramustine and their female partners should use appropriate contraceptive measures (e.g., latex condoms) since this medication can cause serious problems in an unborn child.
Diabetes: Estramustine can cause loss of control of blood glucose levels. Caution and careful monitoring is required when this medication is taken by people with diabetes.
Fluid retention: Estramustine may worsen fluid retention, congestive heart failure and other conditions affected by fluid retention (e.g., epilepsy, migraine, and kidney impairment). Your doctor will monitor you for these problems when necessary.
High blood pressure: Estramustine may increase blood pressure. You should regularly monitor your blood pressure.
Vaccines: You should not be given live vaccines, or be in contact with any person who has received live vaccines, as this may result in serious infections and death. You doctor can tell you which vaccines are safe.
Pregnancy: The safety and effectiveness of using this medication during pregnancy have not been established. Medications similar to estramustine are known to cause harm to an unborn child. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if estramustine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.