Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Dizziness/reduced alertness: This medication may cause dizziness, balance problems, or fatigue. Do not drive, operate machinery, or perform other hazardous tasks until you have determined how this medication affects you.
Heart problems: Heart problems involving symptoms of irregular heart rhythms may be made worse by taking fampridine. If you have heart problems or heart disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Infection: Fampridine may reduce the number of cells that fight infection in the body (white blood cells). Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.
Kidney function: Fampridine is removed from the body by the kidneys. Kidney disease or reduced kidney function can cause this medication to build up in the body, causing side effects and increasing the risk of seizure. People with reduced kidney function or kidney disease should not take fampridine.
If you are taking medications that can impact your kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Seizures: Fampridine has been associated with seizures, even in people who have never had a seizure before. Higher doses of fampridine increase the risk of seizures. The risk of seizures also increases if the kidneys are not working properly. If you have medical conditions that increase your risk of seizures or are taking medications that increase your risk of seizures (e.g., bupropion, tramadol, tapentadol), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with a history of seizures or epilepsy should not take fampridine.
Urinary tract infections: An increase in urinary tract infections has been noted by people taking fampridine. If you experience signs of a urinary tract infection, such as difficult or painful urination, bladder pain, or abdominal pain, contact your doctor as soon as possible.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if fampridine passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Seniors: Seniors are more likely to have reduced kidney function and may therefore be at higher risk of side effects of this medication. Your doctor may test your kidney function before starting treatment with fampridine.