Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Alcohol: A severe set of side effects including nausea, vomiting, and rapid heartbeat may occur if you consume alcohol while taking metronidazole. Although this usually occurs with the oral (taken by mouth) form of metronidazole, it is possible to experience this reaction with the vaginal form of metronidazole. If you are taking this medication, wait until at least one day after finishing treatment before drinking alcohol.
Confusion/dizziness: This medication may cause confusion or dizziness. Avoid driving or other tasks requiring alertness if the medication affects you in this way.
Effectiveness of other products: Condoms and diaphragms may be less effective while using metronidazole - nystatin vaginal cream or ovule. Other methods of birth control should be used while you are taking this medication.
Liver function: Metronidazole may reduce liver function and can cause liver failure. Although this is more common with the form of metronidazole that is taken by mouth, it can occur with the vaginal form. If you have severe liver disease, this medication may build up in the body, causing side effects.
If you have decreased liver function or have had liver problems in the past as a result of taking metronidazole, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function with blood tests while you are taking this medication.
Male partner: When there is evidence of infection in a male sexual partner, he should be treated at the same time with oral metronidazole (taken by mouth) to avoid re-infection.
Neurological side effects: Stop treatment with this medication and see your doctor if muscle incoordination, seizures, or numbness or tingling in the hands or feet occur.
Personal hygiene: Menstrual tampons and soaps with an acid pH should not be used while you are using this medication. These products may promote the growth of fungi, making treatment more difficult.
Side effects: It is possible (but much less likely) that side effects normally associated with the use of oral metronidazole may occur following the use of metronidazole used vaginally.
Underclothing: To help the infection go away more quickly, wear cotton (instead of synthetic) underwear or pantyhose with cotton gussets.
Pregnancy: This medication has not been studied for use by pregnant women. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. The applicator should not be used after the seventh month of pregnancy.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are using metronidazole - nystatin vaginal, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
The safety and effectiveness of using this medication have not been established for children.