Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Allergy: People allergic to other medications in this class (5-hydroxytryptamine agonists such as rizatriptan and naratriptan) can also have an allergic reaction to frovatriptan. If you are allergic to any of these medications, you should not take frovatriptan unless advised to do so by your doctor.
Blood pressure: Frovatriptan may cause an increase in blood pressure. People with severe or uncontrolled high blood pressure should not take frovatriptan.
Drowsiness/reduced alertness: Drowsiness may occur as a result of taking this medication. Do not undertake potentially hazardous activities (e.g., driving or operating machinery) until you have determined that this medication does not make you drowsy.
Heart disease and stroke: This medication may cause narrowing of the blood vessels that supply the heart. This can lead to chest pain, heart attacks, arrhythmias (irregular heartbeat), and other heart problems. There have also been reports of bleeding in the brain and stroke with this medication. For this reason, frovatriptan should not be used by people with heart or blood vessel disease. If you have certain risk factors for heart disease (e.g., high blood pressure, high cholesterol, smoking, obesity, diabetes, family history of coronary artery disease, menopause, men over 40 years of age), tell your doctor.
Liver function: Frovatriptan is not recommended for use by people with severely reduced liver function.
Seizures: People with a history of epilepsy or other conditions that increase their risk for seizure should be closely monitored by their doctor while they are taking this medication.
Serotonin syndrome: This medication may cause a rare but potentially life-threatening condition called serotonin syndrome, especially when used with other medications that increase serotonin levels (e.g., sumatriptan, rizatriptan, St. John's wort, sibutramine, venlafaxine). If you experience symptoms such as agitation, confusion, hallucinations, fast heart rate, fever, lack of coordination, increased body temperature, overactive reflexes, nausea, vomiting, and diarrhea, get immediate medical attention.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if frovatriptan passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children under 18 years of age.
Seniors: There is limited experience with the use of frovatriptan by people over 65 years of age. Its use by seniors is not recommended.