When used in combination with fluorouracil for colon cancer, leucovorin is injected into a vein through a specially prepared site on your skin. In this case, leucovorin is always given under the supervision of a doctor familiar with the use of cancer chemotherapy. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.
The recommended dose for this treatment depends on body size. The treatment is often given once a day for 5 days, just before injection with fluorouracil. This treatment can be repeated every 28 days, depending on response to the therapy.
To prevent methotrexate side effects or to treat overdose, leucovorin can either be given as intravenous (into the vein) or intramuscular (into the muscle) injections. The dose is based on body size and is started between 6 and 24 hours of the start of the methotrexate dose. Leucovorin is given every 6 hours until the blood level of methotrexate is in an acceptable range.
For treatment of megaloblastic anemia due to folic acid deficiency, the dose of leucovorin is based on need as determined by your doctor. Taking leucovorin by mouth is preferred over an injectable form; however, if vomiting prevents enough of the medication from being absorbed, an injectable form may be used. Doses of up to 1 mg daily are used for this condition.
Many things can affect the dose of medication that a person needs, such as body weight, body size, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important to use this medication exactly as prescribed by your doctor.
For the oral (by mouth) form of leucovorin, if you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
For the injectable form of leucovorin, it is important to receive this medication exactly as recommended by your doctor. If you miss an appointment to receive leucovorin, contact your doctor as soon as possible to reschedule your appointment.
Store this medication in a dry place and away from heat and light. Keep this medication out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.