The dose of mitotane depends on response to the medication and the amount of medication that can be tolerated. Usually the starting dose is 9 g to 10 g of mitotane daily in 3 or 4 equally divided doses, with or without food. Your doctor may increase the dose, depending on response, until adverse effects appear. Usually this medication is started in the hospital until a stable dose is reached.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular
dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication away from moisture, heat, and direct light; and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.