Mesna is injected into a vein through a specially prepared site on your skin. The recommended dose is usually 20% of the dose of cyclophosphamide. The injection is given at the time of a cyclophosphamide dose injection, then 4 and 8 hours later.
In the case of ifosfamide, the recommended dose is 10 mg to 12 mg per kilogram of body weight at the time of the ifosfamide dose, and 4 and 8 hours later.
This medication may also be given by mouth under certain circumstances. When this is the case, the dose may be higher than those suggested here.
Mesna may also be given to people being prepared for bone marrow transplantations. Under these circumstances, the doses may be given around the clock for a brief period of time.
Many things can affect the dose and schedule of medication that a person needs, such as body size, other medical conditions, and other medications. Your doctor may choose a different dose or schedule than the ones listed here. Mesna is always given under the direct supervision of your doctor.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.