Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Gastrointestinal perforation: People with advanced illness who use naloxegol may be at increased risk of gastrointestinal perforation (a hole that forms in the wall of the gastrointestinal tract, such as through the stomach or intestines). People are especially at risk if they also have a weakened gastrointestinal wall due to conditions such as cancer, intestinal cancer, or gastrointestinal cancer. If you experience severe, worsening, or persistent abdominal pain that's intensified by movement, or accompanied by fever, chills, nausea or vomiting, seek immediate medical attention. These could be symptoms of gastrointestinal perforation, which is a medical emergency.
Opioid withdrawal: Very rarely, this medication may block the effects of opioids on the nervous system. This can result in symptoms of withdrawal. If you experience unusual sweating, mood swings, nausea or vomiting, muscle aches, tearing, diarrhea, yawning, or difficulty sleeping, contact your doctor.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if naloxegol passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.