Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood clotting: This medication can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily.
Tell your doctor about any signs that your blood is not clotting as quickly as usual. Symptoms include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.
Fertility: Sterility may occur with the use of busulfan.
Gout: This medication may cause high levels of uric acid in the blood, making gout more likely to occur.
Infection: As well as killing cancer cells, this medication can reduce the number of cells that fight infection in the body (white blood cells). Avoid contact with people who have contagious infections and tell your doctor if you begin to notice the signs of an infection such as fever or chills.
Liver: This medication can impair liver function. Your doctor will monitor you for this with blood tests.
Lung disease: This medication may rarely cause a form of lung disease. Contact your doctor immediately if you develop a persistent cough, shortness of breath, or fever. Routine breathing tests may be required.
Seizures: High doses of busulfan can increase the risk of seizures, along with anyone who has a history of seizures, has experienced head trauma, or is receiving other medications which can cause seizures.
Pregnancy: There is a possibility of birth defects if either the father or mother is taking busulfan at the time of conception, or if it is taken during pregnancy. Effective birth control should be practiced while using this medication. If you become pregnant while taking this medication, talk to your doctor immediately.
Breast-feeding: It is not known if busulfan passes into breast milk. Women should not breast-feed while receiving busulfan treatment due to risk of potential harm to the infant.