Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Depression: Apremilast may contribute to episodes of depression or thoughts of self-harm. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, or decreased interest in activities, or notice them in a family member who is taking this medication contact your doctor as soon as possible.
Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Other medications for psoriasis: The safety of using apremilast in combination with other more potent immunosuppressants or biologicals for the treatment of psoriasis has not been studied. If you are using other medications to treat psoriasis, discuss the safety of doing so with your doctor. Because the safety of combining these therapies has not been evaluated, it is not recommended at this time.
Pregnancy: Apremilast should not be used by women who are pregnant, as there is not enough information about the safety of its use during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if apremilast passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. If you are breast-feeding, you should not take this medication.
Children: The safety and effectiveness of using this medication have not been established for children.