Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood pressure: People who take pimozide may develop very low blood pressure causing dizziness and lightheadedness. Some individuals, especially seniors or those who are debilitated, have had temporary low blood pressure for several hours after taking the medication.
Drowsiness/reduced alertness: Pimozide may reduce alertness, especially at the start of treatment. Alcohol may increase these effects. Avoid tasks requiring alertness, such as driving or operating machinery, until you determine if the medication affects you this way.
Epilepsy: Since pimozide may increase the risk of seizures, people with epilepsy should be closely monitored by their doctor while taking this medication.
Grapefruit juice: Grapefruit juice prevents pimozide from being broken down (metabolized) in the body. Avoid drinking grapefruit juice if you take pimozide.
Heart problems: People with heart problems taking pimozide should be closely monitored by their doctor.
Liver disease: People with liver disease should be closely monitored by their doctor while taking this medication because pimozide is broken down (metabolized) in the liver.
Stopping the medication: Do not stop taking this medication without speaking to your doctor. Stopping suddenly may lead to uncomfortable side effects - your doctor may wish to gradually reduce your dose over time.
Tardive dyskinesia (TD): As with all antipsychotic medications, a syndrome called TD may occur for some people on long-term therapy or after they stop taking the medication. The syndrome's main features are rhythmical involuntary movements of the tongue, face, mouth, or jaw. Tell the doctor if you notice these symptoms in yourself or someone else taking pimozide.
Pregnancy: The safe of use of pimozide during pregnancy has not been established. It should not be taken by women who are or may become pregnant, particularly during the first trimester of pregnancy, unless in the opinion of the doctor the benefits outweigh the risks.
Breast-feeding: Pimozide may pass into breast milk. If taking pimozide is considered essential, stop breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children. Pimozide is not recommended for children.