Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breastfeeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Abnormal heart rhythms: This medication can increase the risk of serious abnormal heart rhythms. People with heart disease such as congenital or acquired QT prolongation, congestive heart failure, a slow heartbeat, heart attack, low blood potassium levels, or who are taking medications that can prolong the QT interval (e.g., amitriptyline, methadone, erythromycin, procainamide, amiodarone, sotaolol, haloperidol) should discuss with their doctor how this medication may affect their medical condition and whether any special monitoring is needed.
Allergy to other antifungals: If you are allergic to antifungals that are related to posaconazole (e.g., ketoconazole, fluconazole, itraconazole, or voriconazole), your doctor will monitor you closely while you are taking this medication. If you experience any symptoms of an allergic reaction such as a rash, contact your doctor immediately. If you experience symptoms of a serious allergic reaction (hives; difficulty breathing; swelling of the face, mouth, tongue, or throat), get immediate medical attention.
Blood problems: Rarely, serious blood problems (e.g., hemolytic uremic syndrome, thromobotic thrombocytopenic purpura) can occur while taking this medication. If you experience vomiting, diarrhea, blood in the stools, weakness, paleness, bruising, confusion, fever, contact your doctor immediately. These rare but serious blood problems are more likely to occur when people are also taking cyclosporine or tacrolimus to prevent transplant rejection.
Glucose: The oral suspension contains glucose. People with galactose or glucose-galactose malabsorption should check with their doctor before taking this medication.
Liver problems: This medication can cause liver problems. Some people experience increases in liver function tests while taking posaconazole. These increases usually return to normal when posaconazole is stopped, and may return to normal without stopping treatment. Some people may experience symptoms of more severe liver problems (nausea, vomiting, abdominal pain, fatigue, yellowing of the skin or eyes, light coloured stools) while taking this medication. If you experience any of these symptoms, contact your doctor immediately. Your doctor will monitor your liver function while you are taking posaconazole.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. Women who may become pregnant should use adequate contraception while taking this medication. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if posaconazole passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children under 13 years of age.