The recommended dose of evolocumab to treat primary hyperlipidemia is 140 mg injected subcutaneously (under the skin) every 2 weeks or 420 mg injected subcutaneously once a month.
To treat homozygous family hyperlipidemia, the starting dose is 420 mg injected once monthly. After 3 months, your doctor may increase your dose to 420 mg every 2 weeks, depending on your response to this medication.
If your dose is 420 mg, you will use 3 prefilled syringes injected one after the other, within 30 minutes. Before injecting the medication, allow it to sit at room temperature for 30 minutes. Do not warm it in any other way. Subcutaneous injections are administered in the abdomen, upper arm, or thigh area. Do not use the injection if it is discolored, cloudy, or if you can see particles in the solution.
If you are injecting this medication yourself, your doctor will show you how to use this medication properly. If you are not sure how to use it or have questions about how to use it, contact your doctor. Before using this medication, thoroughly read the patient information provided and ask your doctor if you have any questions. If a family member or caregiver will be giving you the injections, your doctor should instruct them on how to give the injection.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and contact your doctor to find out when you should inject your next dose. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication in the refrigerator, protect it from light and moisture, and keep it out of the reach of children. Do not freeze or shake this medication. Once it is removed from the refrigerator, it may be stored at room temperature for 30 days.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.