Replagalis no longer being manufactured for sale in Canada and is no longer available under any brand names. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergic and infusion-related reactions: This medication can cause allergic reactions, some of which can be severe. You will receive this medication under close medical supervision, especially at the beginning of treatment.
Most people develop antibodies when treated with enzyme replacement therapy. If you develop antibodies to agalsidase alfa, you might experience allergic side effects such as an infusion-related reaction. The antibodies are not likely to stop this medication from working and will decrease with time. Infusion-related reactions can include chills and fever and usually start within the first 2 to 4 months of treatment.
If you experience an infusion-related reaction, your doctor can decrease the infusion rate or treat the reaction with other medications (e.g., acetaminophen, ibuprofen, antihistamines, or corticosteroids).
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if agalsidase alfa passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Seniors: The safety and effectiveness of using this medication have not been established for seniors.