Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Alcohol: Do not consume alcohol while taking this medication. Alcohol can increase the risk of liver problems with this medication.
Antibiotic-associated colitis: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated, or pseudomembranous, colitis. Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking rifampin - isoniazid - pyrazinamide and contact your doctor as soon as possible.
Birth control: Rifampin can reduce the effectiveness of birth control pills. It is important to use a backup method to contraception (i.e., latex condom) until rifampin - isoniazid - pyrazinamide therapy is finished.
Diabetes: This medication may raise blood glucose levels. People with diabetes should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Discoloration of body fluids: Rifampin may cause discoloration of body fluids (e.g., tears, sweat, saliva, or urine) to an orange-to-red colour. This side effect is not harmful. It may also stain soft contact lenses. You may want to consider wearing eyeglasses while taking this medication to avoid staining your contact lenses.
Eye problems: This medication may cause eye and vision problems. Your doctor will recommend regular eye examinations while you are taking this medication. If you experience any changes to your vision while taking rifampin - isoniazid - pyrazinamide, contact your doctor as soon as possible.
Food restriction: Isoniazid can interact with several types of food, especially those with high amounts of tyramine (e.g., cheese, beer, red wine, rye bread) and histamine (e.g., tuna and other tropical fish). Side effects include headache, sweating, flushing, low blood pressure, and dizziness. While using rifampin - isoniazid - pyrazinamide, try to avoid foods high in tyramine and histamine.
Gout: Rifampin - isoniazid - pyrazinamide can increase the levels of uric acid in the blood, increasing the risk of developing gout. Your doctor will monitor your blood uric acid levels while you are taking this medication.
If you develop painful, warm and swollen joints or difficulty with urination, contact your doctor as soon as possible.
People with a history of gout or kidney stones should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney function: People with decreased kidney function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: This combination medication contains 3 ingredients that can all cause liver problems. The liver effects can be serious and fatal, and can occur many months after treatment. The risk for liver problems increases with age and with daily alcohol intake. Your doctor will perform tests regularly to monitor your liver function. If you experience any symptoms of liver damage (e.g., yellowing of skin or eyes, darkened urine, light-coloured stools, loss of appetite, nausea, vomiting, fever, or unusual tiredness), contact your doctor immediately.
People with severe liver damage or active liver disease should not take this medication.
Pregnancy: The effect of these medications on an unborn baby is unclear. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Rifampin, isoniazid, and pyrazinamide pass into breast milk. If you are a breast-feeding mother and are taking rifampin - isoniazid - pyrazinamide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The combination of these medications in the strengths contained in this product is not appropriate for children. Higher doses (per kilogram of body weight) of some medications are needed, while lower doses of other medications are needed. Although the individual medications are used to treat tuberculosis in children, this product is not considered appropriate.