Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Alcohol use: The use of zolpidem after consuming alcohol increases the risk of severe side effects such as breathing difficulty and performing activities while not being aware or awake. Alcohol should not be consumed if you are taking zolpidem.
Allergic reaction: In rare cases, people have developed a serious allergic reaction to medications like zolpidem involving swelling of the tongue, glottis, or larynx. Some people have had shortness of breath, nausea, vomiting, or throat closing.
Other signs of an allergic reaction include a severe rash, hives, swollen face or throat, or difficulty breathing. If you experience any of these symptoms after taking zolpidem, seek immediate medical attention.
Behaviour changes: This medication may cause agitated or aggressive behaviour. If you experience these symptoms or any other behaviour change while taking this medication, contact your doctor immediately.
Family members or caregivers of people who are taking this medication should contact the person's doctor immediately if they notice unusual behaviour changes.
Breathing problems: Zolpidem can suppress breathing. If you are at risk for breathing difficulties, such as asthma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Confusion: This medication affects mental efficiency (e.g., concentration, attention, and vigilance). The risk of confusion is greater for seniors and those with brain damage.
Dependence and withdrawal: Physical dependence, psychological dependence, and abuse have occurred with the use of zolpidem. If you have a history of past or current substance use problems you may be at greater risk of developing abuse or addiction while taking this medication.
Withdrawal symptoms have been observed after stopping the medication suddenly (after having taken it regularly over a period of time). These symptoms include:
- abdominal cramps
- memory impairment
- sleep problems such as rebound insomnia
If you have been taking this medication for longer than 10 days, discuss with your doctor the best way to stop zolpidem.
Depression: Medications used for sleep disturbances have been known to cause mood swings and symptoms of depression. Zolpidem may worsen symptoms of depression, including thoughts of suicide or wanting to harm others.
If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, or decreased interest in activities, or notice them in a family member who is taking this medication, contact your doctor as soon as possible.
Drowsiness/reduced alertness: Zolpidem can cause excessive daytime drowsiness and decreased mental alertness. Do not drive, operate machinery, or perform other dangerous tasks until you know how this medication affects you.
Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
Memory disturbance: Although rare, amnesia of varying severity has been reported following normal doses of medications like zolpidem. This is an unpredictable effect of the medication. If you experience any memory problems while taking this medication, contact your doctor.
Performing activities while not fully awake: People taking zolpidem may perform activities such as sleepwalking, driving, preparing and eating food, and making phone calls while not fully awake and are unaware of their actions. The next morning, they may not remember what happened. This may be more likely to occur if you use alcohol or other sedative medications. If you discover this has happened to you, contact your doctor immediately.
Family members or caregivers of people who are taking this medication should contact the person's doctor immediately if they notice any of these unusual behaviours.
Rebound insomnia: As with other medications used to aid in sleeping, you may experience a temporary return of your sleeping difficulties when zolpidem is stopped.
Pregnancy: The use of zolpidem during pregnancy has not been studied. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking zolpidem, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of zolpidem have not been established for use by children and adolescents less than 18 years of age.
Seniors: People over 65 years of age are more likely to experience dose-related side effects of zolpidem, such as drowsiness, dizziness, or impaired coordination. Lower doses of zolpidem are recommended for seniors.