Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Allergies: Be cautious in taking fluconazole if you are allergic to other "azoles" such as ketoconazole or itraconazole. If you develop symptoms of an allergic reaction, such as skin rash, hives, difficulty breathing, or swelling of the face, tongue, or throat, seek immediate medical attention.
Driving and operating heavy machinery: Fluconazole may occasionally cause dizziness. Do not drive or operate machinery until you know how this medication affects you.
Kidney function: People with kidney disease or reduced kidney function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver damage: In rare cases, this medication may cause liver damage in people with serious medical conditions. Your doctor may monitor you with regular blood tests to check for side effects while you are taking fluconazole. If you notice signs of liver damage such as abdominal pain, yellowing of the skin or eyes, dark or amber urine, or pale stools, contact your doctor right away.
QT prolongation: In rare cases, this medication can affect the electrical activity of the heart and cause a condition known as QT prolongation. Your doctor will monitor your heart rhythm regularly while you are taking this medication with a test called an electrocardiogram (ECG). You should not take this medication if your ECG already shows that you have QT prolongation or if you are taking a medication that can cause QT prolongation.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. Women who take fluconazole for vaginal yeast infections and who may become pregnant should consider using adequate birth control.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking fluconazole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: This medication has been shown to be safe and effective for children over 6 months of age.