Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood clots: A blood clot in the vein is a possible side effect of raloxifene. If you have a history of blood clots, including in the legs, lungs, or eyes, taking this medication may increase the risk of getting blood clots. Talk to your doctor if you have any concerns. If you experience any symptoms of blood clots (see "What side effects are possible with this medication?"), stop taking the medication and contact your doctor as soon as possible.
Calcium and vitamin D: It is important that you are receiving the recommended amount of calcium and vitamin D each day. If you are not getting enough from your diet, your health care provider may recommend you take vitamin D and calcium supplements. Talk to your health care provider about the amount of calcium and vitamin D you should be receiving.
Effect on uterus, breast, and mental function: Raloxifene is not associated with side effects on the uterus, breast, or mental function. Therefore, if you experience unexplained uterine bleeding, breast pain, breast enlargement, changes in mood, or deterioration of mental function, contact your doctor as soon as possible.
Liver: People who have liver disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Men: This medication is not for use by men.
Prolonged inactivity: Because of an increased risk of blood clots, raloxifene should be stopped at least 72 hours before and during long periods of inactivity (e.g., after surgery, prolonged bed rest).
Stroke and heart disease: Women taking raloxifene and who have had a heart attack or are at risk for a heart attack may have an increased risk dying from stroke. Talk to your doctor if you have any concerns.
Women who have not reached menopause: The safety and effectiveness of using this medication have not been established for women who have not reached menopause. This medication should not be used by premenopausal women.
Pregnancy: This medication should not be used during pregnancy.
Breast-feeding: It is not known if raloxifene passes into breast milk. This medication should not be used by women who are breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children. This medication should not be used by children.