Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Blood clotting: This medication can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily. Tell your doctor of any signs that your blood is not clotting as quickly. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.
Infection: As well as killing cancer cells, this medication can reduce the number of cells that fight infection in the body (white blood cells). Avoid contact with people with contagious infections and tell your doctor if you notice signs of an infection, such as fever or chills.
Pregnancy: Raltitrexed may harm the baby if used during pregnancy. It should not be used during pregnancy, and pregnancy should be avoided (by using effective birth control) during treatment and for at least 6 months after treatment of either parent. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Because of the risks associated with raltitrexed, a decision should be made to cease breast-feeding or to discontinue the medication, taking into account the importance of the medication to the mother.