Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
May 28, 2014
Health Canada has issued new restrictions concerning the use of Vectibix (panitumumab). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Allergic and infusion reactions: This medication can cause allergic reactions and side effects that are related to receiving the infusion. Some of these reactions can be severe. If you experience shortness of breath, wheezing, fever, chills, lightheadedness, dizziness, or swelling of the face and throat while receiving this medication, tell your doctor immediately or get immediate medical attention.
Diarrhea: This medication can cause diarrhea that can lead to dehydration (loss of too much water from the body). If you experience severe diarrhea for more than a day, or if you have diarrhea along with fever, decreased urination, dizziness, or a fast heartbeat, contact your doctor immediately.
Kidney and liver problems: The safety and effectiveness of using this medication have not been established for people with liver or kidney problems.
Lung problems: Panitumumab and similar medications can cause lung problems. If you experience difficulty breathing or shortness of breath while you are taking this medication, contact your doctor immediately.
If you have or have had interstitial pneumonitis (swelling of the lungs causing cough and difficulty breathing) or pulmonary fibrosis (scarring and thickening in the lungs with shortness of breath), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Skin reactions: This medication commonly causes skin reactions. Some of these reactions can be severe. If you experience skin redness, itching, rash, peeling, cracks, dryness, or swelling and inflammation around the nails, contact your doctor. Since sunlight may worsen skin reactions caused by this medication, people taking it should wear sunscreen and a hat, and limit sun exposure.
Pregnancy: Panitumumab should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if panitumumab passes into breast milk. If you are taking this medication, you should not breast-feed during treatment and for 2 months after the last dose.
Children: The safety and effectiveness of using this medication have not been established for children under 18 years of age.