Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Diabetes: If you have diabetes, your doctor should closely monitor your condition while you are taking metolazone, as it may affect blood sugar control (by increasing blood sugar levels).
Electrolytes: Metolazone may cause imbalances of electrolytes in the blood such as potassium, sodium, and magnesium. The signs of electrolyte imbalance include:
- dry mouth
- low blood pressure
- muscle fatigue
- muscle pains or cramps
- racing heart rate
- reduced urine output
- stomach disturbances such as nausea and vomiting
If you have these symptoms, contact your doctor as soon as possible.
Gout: High blood uric acid levels may be brought on by metolazone. This may result in a gout attack for people with a history of gout. If you have a history of gout, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Kidney and liver function: If you have reduced kidney or liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking metolazone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.