If you are a postmenopausal woman using 10 mg AIE per day or more, consult a health care practitioner if:
- you are using thyroid hormone replacement therapy
- you have a liver disorder or liver-related symptoms such as dark urine and jaundice
If you are a postmenopausal woman using 30 mg AIE per day or more, consult a health care practitioner if:
- you have a history of disease related to female hormone such as ovarian cancer, uterine fibroids or endometriosis
- you experience symptoms such as breast pain, soreness, tenderness, or uterine bleeding after starting red clover
- you are taking hormone replacement therapy
In addition, anytime when the symptoms worsen, you should consult a health care practitioner. You should not use products containing 30 mg AIE or more of red clover if you have had breast cancer or if you are at a high risk of having breast cancer.
Currently, the evidence is conflicting for the effect of red clover on menopausal and postmenopausal symptoms. There is not enough scientific evidence to determine whether red clover is effective for any other health conditions.
Red clover seems to be safe for most adults when used for short periods of time. No serious adverse effects have been reported.
Because red clover contains estrogen-like compounds, there is a possibility that its long-term use may increase the risk of women developing cancer of the lining of the uterus. However, studies to date have been too brief (less than 6 months) to evaluate whether red clover has estrogen-like effects on the uterus. Likewise, red clover may interfere with medications that use estrogen receptors such as oral contraceptive drugs and estrogen replacement therapy.
It is unclear whether red clover is safe for women who are pregnant or breast-feeding, or who have breast cancer or other hormone-sensitive cancers.
Before taking any new medications, including natural health products, speak to your physician, pharmacist, or other health care provider. Tell your health care provider about any natural health products you may be taking.