Riboflavin appears to be safe for most people when taken at the daily recommended dose. Ribofavin is water-soluble and any excess will be readily excreted out of the body in the urine. Because of this, a common side effect is dark yellow or orange urine. Diarrhea, an increase in urine, light sensitivity, and numbness or a burning sensation have also been reported when taking larger amounts of riboflavin.
Riboflavin is likely safe for pregnant and breastfeeding women, as long as they do not take more than the daily recommended doses.
The following medications may interact with riboflavin:
- anticholinergic agents
- tricyclic antidepressants (when taken in large amounts)
- phenobarbital (a medication used for seizures)
- probenecid (a medication used to treat gout)
The following herbs and supplements may also interact with riboflavin:
- blond psyllium
- iron supplements
Riboflavin is quickly destroyed when exposed to light, so foods containing riboflavin should be protected from light.
Before taking any new medications, including natural health products, speak to your physician, pharmacist, or other health care provider. Tell your health care provider about any natural health products you may be taking.